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The CAARMS: Assessing Young People at Ultra High Risk of Psychosis. This manual is aimed at mental health professionals working with young people who. Mapping the Onset of Psychosis: The Comprehensive Assessment of At-Risk Mental . To assess predictive validity, the CAARMS-defined UHR criteria were. Comprehensive Assessment of At-Risk Mental States (CAARMS; the CAARMS before assessing psychosis risk, either through their headspace centre or.

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This study had limitations. The primary aim of the study was investigated by comparing the peychosis outcomes i. Psychosiz pragmatic algorithm to convert individual cases across the SIPS 5.

Post hoc analyses see eTable 3 confirmed an overall substantial agreement across the two instruments with the exception of the cell [2,5: Differences remain between the characteristics of the basic population, the recruitment of patients, the follow-up, and the specific treatments provided [ 9 ].

Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States.

To better elucidate these differences we have conducted a qualitative analysis of psychopathological characteristics of these 14 patients, which is appended in eTable 4. It is possible to speculate that the additional SIPS 5.

Also, the functional decline criterion i. External validation was performed in an independent sample assessed for suspicion of UHR symptoms at the Seoul Youth Clinic see eTable 5.

Mapping the onset of psychosis: the Comprehensive Assessment of At-Risk Mental States.

The kappa remained substantial when it was estimated in the subset of subjects rated by independent raters overall agreement Interpretation of the kappa values varies, but some guidelines were provided by Landis and Koch for kappa coefficients suggesting that kappa of 0. The authors thank Professor Scott Woods for his external advice on the use of the SIPS and on his personal comments on the disorganized and dangerous symptoms.


The ROC area serves as a global measure of test performance and values in the range of 0. However, assessing subjects referred for suspicion of UHR symptoms at the time of the first contacts with high-risk services who may be already psychotic or eventually deemed not at risk of psychosis with independent raters poses severe logistic difficulties for the patients.

For the SIPS 5. The secondary aim of the study was investigated using post hoc explorative residual analyses comparing different subgroups i.

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Indeed, the definition of case spychosis. Our results are thus highly relevant to permit overall meaningful comparisons of clinical, neurobiological, neurocognitive, and cost-effectiveness UHR studies worldwide, with potential beneficial impact for ongoing large-scale multicentre UHR projects such as the PRONIA http: We additionally estimated the prevalence and bias adjusted kappa PABAK [ 21 ] which adjusts the kappa for imbalances caused by differences in prevalence and bias [ 22 ].

Such a substantial agreement is not completely surprising. Avoiding the use of external and non-help-seeking control psychoais who do not reflect the clinical composition of people actually assessed in high pscyhosis is essential to properly compare the diagnostic abilities of the two instruments.

The development of psychometric tools to prospectively identify subjects at ultra high clinical risk UHR hereafter of psychosis has allowed preventative screening [ 1 ], diagnosis [ 2 ], and interventions [ 3 ] to be feasible in psychiatry.


A software engineer JL then implemented psychsis conversion algorithm in an automated package. These findings however may be influenced by the type of recruitment strategies adopted by the high-risk services.

This method is detailed in eMethod 2. To freely download the tool and the template. This algorithm has been implemented in the CONVERT tool, which has been made freely available for the use of future researchers and clinicians and externally validated in an independent sample.

Furthermore, we only included subjects who were directly assessed with both psychometric instruments during face-to-face interviews, excluding those who declined the full assessment or who were unable to complete it. Our secondary aim was to qualitatively investigate potential discrepancies across the two instruments and to provide equipercentile-linking comparisons.

However, their operationalization differs [ 10 ], with substantial psycyosis over different versions of the instruments [ 10 ]. Woods, The Psychosis-Risk Syndrome: The count in this cell was statistically higher than the count expected by chance. The automated conversion algorithm CONVERT to convert individual cases was validated in an independent sample and showed an excellent accuracy.

Subscribe to Table of Contents Alerts. CAMEO was started in and it is an early intervention in psychosis service which offers management for UHR people aged 17—35 in Cambridgeshire, UK, and provides initial assessments to those under


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