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Objective: We performed a systematic review and meta-analysis of published demiological studies of developmental fluo-. ride neurotoxicity. Developmental Fluoride Neurotoxicity: Choi et al. Respond . fluoride neurotoxicity: a systematic review and meta-. analysis. Environ Health. “Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis” is a study published in Environmental Health.

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Among the two covariates, year of publication 0.

Developmental fluoride neurotoxicity: a systematic review and meta-analysis.

The study with a positive association reported an SMD estimate of 0. Six of the 34 studies identified were excluded because of missing information on the number of subjects or the mean and variance of the outcome [see Figure 1 for a study selection flow chart and Supplemental Material, Table S1 http: The diversity across the included studies and the substantial potential for bias due to confounding by xnd factors meant that the results of this review may not be reliable.

We evaluated the potential for publication bias using Begg and Egger tests and visual inspection of a Begg funnel plot Begg and Mazumdar ; Egger et al. Articles from EHP, especially the Neurotoixcity section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining fluorid approval from the holder of the copyright.

Exclude studies with other exposures iodine, arsenic c or non-drinking-water fluoride exposured.

The effect of age and year of publication were investigated using meta-regression. A suitable search was performed which included a relevant Chinese database. It is not a conclusive study nor can it be represented as definitive evidence of a link between fluoride ststematic lower IQs in children. Message for DARE database users. This developpmental is a systematic review and meta-analysis of 27 previously published studies.


Finally, the article has no application to fluoride levels in U.

Exclude nonstandardized testsa 23 —0. Fluoride in Drinking Water: External links Twitter Facebook Discord. Among the restricted sets of intelligence tests, the SMD for the model with only CRT-RC tests and drinking-water exposure and to a lesser extent the model with only CRT-RC tests was lower than that for all studies combined, although the difference did not appear to be significant.

However, if you neurotixicity read the paper and look at Table 1, the meta-analysks compared children in areas with recommended levels of fluoride in water — the same levels that are introduced in the process of water fluoridation 0. The estimate of the between-study variation is incorporated into both the SE of developmmental estimate of the common effect and the weight of individual studies, which was calculated as the inverse sum of the within and between study variance.

Developmental Fluoride Neurotoxicity: A Systematic Review and Meta-Analysis

The fact that some aspects of the study were not reported limits the extent to which the available reports allow a firm conclusion. Studies were combined in suitable meta-analyses. Community Dent Oral Epidem. Mean IQ score was significantly lower in children who lived in the high-fluoride area than that of children in the reference exposure area both areas also had arsenic exposure.


Int J Pediatr Dent.

By clicking accept reivew continuing to use the site, you agree to the terms outlined in our Privacy PolicyTerms of Serviceand Dataset License. The latter showed that dose-related deficits were found, but the studies were excluded because our meta-analysis focused on studies with the high- and low-exposure groups only.

Further subgroup develomental were reported in the paper. A preliminary exploration of IQ of 7—13 year old pupils in a fluorosis area with contamination from burning coal.

These variables were therefore not included in the models. Twenty-seven studies were included in the meta-analysis with sample sizes that ranged from 60 to children. Survey of drinking water quality in Jintang County. Developmental neurotoxicity of industrial chemicals. Occupational fluorosis through 50 years: We carried out an extensive review that includes epidemiological studies carried out in China.

Several studies Hong et al. Fluoride exposure was mostly through drinking water, but three studies assessed exposure due to coal burning. We specifically targeted studies carried out in rural China that have not been widely meta-analjsis, thus complementing the studies that have been included in previous reviews and risk assessment reports.


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