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FORMULASI SUSPENSION PDF

Keywords: Dry suspension, Taste Masking, Macrolide Antibiotic, Eudragit L . formula F = Vu/Vo, where Vu is the volume of sediment and Vo. Route Dosage Form. Concentration. Sulfamethoxazole-Trimethoprim Oral Suspension 40mg/5mL. Formula Qty: mL. Shelf Life: 20 days. Hospital Of Eastern Ontario. MASTER FORMULA SHEET – NON-STERILE MANUFACTURING. PRODUCT: PROPRANOLOL 5 mg/mL ORAL SUSPENSION .

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The stability of the amorphous form of cefuroxime axetil in solid state. Port City Press; Please review our privacy policy.

Percentage of release for all selected formulations.

For suspension formulation equivalent to mg of cefuroxime was suspended in 5 ml vehicle, after selecting the type and concentration of wetting agent, other ingredients such as flocculating agents, suspending agents, preservatives and flavors were added.

Made formulations are then evaluated for physical stability tests in which the sedimentation volume the ratio of the final volume of the sediment to the original volume of the suspension and degree of flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.

Received Aug 28; Accepted Nov Tabibi S, Rhodes CH. Journal List Adv Pharm Bull v. According to the obtained results and considering the ideal characteristics of prepared suspension formulations, this product can be added to drug market. It is characterized by being the only second-generation cephalosporin which adequately penetratesinto the cerebrospinal fluid CSF.

Discussion General criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and homogeneity, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no crystal growth and appropriate pour ability.

The authors would like to thank Dana Pharmaceutical Co. The potential of the moving layer around each particle is called zeta potential. Since cefuroxime is not absorbed orally, the 1-acetyloxyethyl axetil ester of cefuroxime was used to improve its gastrointestinal absorption.

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This article is based on a thesis submitted for Pharm Dr degree No. Oral route is the selective method for administration of most of the drugs. The sedimentation volume was calculated to be 1 in all the suspensions, therefore there was no need to re-dispersion test and the degree of flocculation value was also 1.

Remington the science and practice of Pharmacy. Support Center Support Center. One of the methods for making the suspension, is the dispersion of a particle in a vehicle that can be done by mechanical instruments or by the use of surfactants that contains three steps: Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability.

Published online Dec Percent of labeled amount. For 3 of each formulation, dissolution test was performed with USP 2 apparatus Paddle in 50 rpm for 30 minutes. Eur J Pharm Sci. The charge of the particles effects their distribution in the environment and increases the concentration of opposite charge on the surface close to them which produces electric double layer.

Table 1 Composition of selected formulations designed in Minitab ver. General criteria for selecting a suitable suspension can be considered as proper appearance of uniformity and suspensio, the number of low-frequency shaking for the complete distribution, the high volume of sediment, no crystal growth and appropriate pour ability. Then using equation derived from calibration curve.

Results From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed in the Table 1.

From all 33 formulations designed in Minitab software, only 9 was selected to further investigation that are listed in the Table 1. Evaluation of physical stability Made formulations are then evaluated formulazi physical stability tests in which the sedimentation volume the ratio of the final volume of the sediment to the original volume of the suspension and degree of flocculation the ratio of the ultimate sediment volume of flocculated suspension to the ultimate sediment volume of deflocculated suspension were conducted.

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Acknowledgement The authors would like to thank Dana Pharmaceutical Co. National Center for Biotechnology InformationU. According to the curve each formulation released Considering no sedimentation, the sedimentation volume was determined to be 1.

The viscosity curves showed that the systems were pseudo plastic and thixotrop. J Pharm Biomed Anal. A sample of these curves is shown in Figure 2.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

After selecting the acceptable preparations, physical stability tests and other tests such as dissolution rate, pH, zeta potential and viscosity measurement of formulations were performed. Author information Article notes For,ulasi and License information Disclaimer.

After calculating the viscosity, the curves of viscosity against shear rate were plotted. Eur J Pharm Biopharm. Dissolution test For 3 of each formulation, dissolution test was performed with USP 2 apparatus Paddle in 50 rpm for 30 minutes. An advantage of cefuroxime over other second-generation cephalosporins is that it is effective in the treatment of Neisseria gonorrhea and H influenzae.

Cefuroxime is the second generation cephalosporin, which its intravenous and oral dosage forms are available.

Formulation of cefuroxime axetil oral suspension and investigation of its pharmaceutical properties

A sample viscosity curve for formulated suspension. From all 33 formulations, only 9 were selected to further investigation.

This article has been cited by other articles in PMC. Considering the differences of the viscosity in up and down curves the thixotropy of the system is obvious so the vehicle was pseudo plastic and thixotrop.

Also the system was found to be time-depended. Bioequivalence evaluation of two brands of cefuroxime mg tablets cefuzime and zinnat in healthy volunteers.

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